| Tissue Specificity | Found in most tissues. |
| Post Translational Modifications | Phosphorylation by PAK1 is required for normal function. Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome. (Microbial infection) Glycosylated residues by S.typhimurium protein Ssek1: arginine GlcNAcylation promotes microtubule stability. |
| Function | Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer. Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth. |
| Protein Name | Tubulin-Folding Cofactor BCytoskeleton-Associated Protein 1Cytoskeleton-Associated Protein CkapiTubulin-Specific Chaperone B |
| Database Links | Reactome: R-HSA-389977 |
| Cellular Localisation | CytoplasmCytoskeletonColocalizes With MicrotubulesIn Differentiated NeuronsLocated In The CytoplasmIn Differentiating NeuronsAccumulates At The Growth Cone |
| Alternative Antibody Names | Anti-Tubulin-Folding Cofactor B antibodyAnti-Cytoskeleton-Associated Protein 1 antibodyAnti-Cytoskeleton-Associated Protein Ckapi antibodyAnti-Tubulin-Specific Chaperone B antibodyAnti-TBCB antibodyAnti-CG22 antibodyAnti-CKAP1 antibody |
Information sourced from Uniprot.org
