| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ST8SIA1 (49-270) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:2000-1:9000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ST8SIA1 |
| Gene ID: |
6489 |
| Uniprot ID: |
SIA8A_HUMAN |
| Immunogen Region: |
49-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 49-270 of human ST8SIA1 (NP_003025.1). |
| Immunogen Sequence: |
YRLPNEKEIVQGVLQQGTAW RRNQTAARAFRKQMEDCCDP AHLFAMTKMNSPMGKSMWYD GEFLYSFTIDNSTYSLFPQA TPFQLPLKKCAVVGNGGILK KSGCGRQIDEANFVMRCNLP PLSSEYTKDVGSKSQLVTAN PSIIRQRFQNLLWSRKTFVD NMKIYNHSYIYMPAFSMKTG TEPSLRVYYTLSDVGANQTV LFANPNFLRSIGKFWKSRGI HA |
| Tissue Specificity | Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung. |
| Function | Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3.gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3. Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively. Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells. |
| Protein Name | Alpha-N-Acetylneuraminide Alpha-2 -8-SialyltransferaseAlpha-2 -8-Sialyltransferase 8aGanglioside Gd3 SynthaseGanglioside Gt3 SynthaseSialyltransferase 8aSiat8-ASialyltransferase St8sia ISt8siai |
| Database Links | Reactome: R-HSA-4085001 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Alpha-N-Acetylneuraminide Alpha-2 -8-Sialyltransferase antibodyAnti-Alpha-2 -8-Sialyltransferase 8a antibodyAnti-Ganglioside Gd3 Synthase antibodyAnti-Ganglioside Gt3 Synthase antibodyAnti-Sialyltransferase 8a antibodyAnti-Siat8-A antibodyAnti-Sialyltransferase St8sia I antibodyAnti-St8siai antibodyAnti-ST8SIA1 antibodyAnti-SIAT8 antibodyAnti-SIAT8A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
