| Tissue Specificity | Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung. |
| Function | Catalyzes the addition of sialic acid in alpha 2,8-linkage to the sialic acid moiety of the ganglioside GM3 to form ganglioside GD3.gangliosides are a subfamily of complex glycosphingolipds that contain one or more residues of sialic acid. Can catalyze the addition of a second alpha-2,8-sialic acid to GD3 to form GT3. Can use GM1b, GD1a and GT1b as acceptor substrates to synthesize GD1c, GT1a and GQ1b respectively. Can synthesize unusual tetra- and pentasialylated lactosylceramide derivatives identified as GQ3 (II3Neu5Ac4-Gg2Cer) and GP3 (II3Neu5Ac5-Gg2Cer) in breast cancer cells. |
| Protein Name | Alpha-N-Acetylneuraminide Alpha-2 -8-SialyltransferaseAlpha-2 -8-Sialyltransferase 8aGanglioside Gd3 SynthaseGanglioside Gt3 SynthaseSialyltransferase 8aSiat8-ASialyltransferase St8sia ISt8siai |
| Database Links | Reactome: R-HSA-4085001 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Alpha-N-Acetylneuraminide Alpha-2 -8-Sialyltransferase antibodyAnti-Alpha-2 -8-Sialyltransferase 8a antibodyAnti-Ganglioside Gd3 Synthase antibodyAnti-Ganglioside Gt3 Synthase antibodyAnti-Sialyltransferase 8a antibodyAnti-Siat8-A antibodyAnti-Sialyltransferase St8sia I antibodyAnti-St8siai antibodyAnti-ST8SIA1 antibodyAnti-SIAT8 antibodyAnti-SIAT8A antibody |
Information sourced from Uniprot.org
