| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SP140 (1-180) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SP140 |
| Gene ID: |
11262 |
| Uniprot ID: |
SP140_HUMAN |
| Immunogen Region: |
1-180 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SP140 (NP_001265380). |
| Immunogen Sequence: |
MAQQGQQGQMASGDSNLNFR MVAEIQNVEGQNLQEQVCPE PIFRFFRENKVEIASAITRP FPFLMGLRDRSFISEQMYEH FQEAFRNLVPVTRVMYCVLS ELEKTFGWSHLEALFSRINL MAYPDLNEIYRSFQNVCYEH SPLQMNNVNDLEDRPRLLPY GKQENSNACHEMDDIAVPQE |
| Tissue Specificity | High levels in spleen and peripheral blood leukocytes, much lower levels in tonsils, thymus, prostate, ovary, small intestine, and colon. Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not detected in brain, liver and muscle. |
| Post Translational Modifications | Phosphorylation at Thr-726 promotes binding of PIN1 and subsequent isomerization of Pro-727. |
| Function | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails. |
| Protein Name | Nuclear Body Protein Sp140Lymphoid-Restricted Homolog Of Sp100Lysp100Nuclear Autoantigen Sp-140Speckled 140 Kda |
| Cellular Localisation | NucleusPml BodyCytoplasmLocalized To Nuclear Structures Termed LandsFor Lysp100-Associated Nuclear DomainsLands Are GlobularElectron-Dense Structures Most Often Found In The NucleoplasmBut Also Found At The Nuclear Membrane And In The CytoplasmSuggesting That These Structures May Traffic Between The Cytoplasm And The NucleusAlso Colocalizes With Pml In A Subset Of Pml Nuclear Bodies |
| Alternative Antibody Names | Anti-Nuclear Body Protein Sp140 antibodyAnti-Lymphoid-Restricted Homolog Of Sp100 antibodyAnti-Lysp100 antibodyAnti-Nuclear Autoantigen Sp-140 antibodyAnti-Speckled 140 Kda antibodyAnti-SP140 antibodyAnti-LYSP100 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
