Anti-SLC25A12 antibody (1-180) (STJ113288)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC25A12 (1-180) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC25A12 |
| Gene ID | 8604 |
| Uniprot ID | S2512_HUMAN |
| Immunogen Region | 1-180 |
| Immunogen Sequence | MAVKVQTTKRGDPHELRNIF LQYASTEVDGERYMTPEDFV QRYLGLYNDPNSNPKIVQLL AGVADQTKDGLISYQEFLAF ESVLCAPDSMFIVAFQLFDK SGNGEVTFENVKEIFGQTII HHHIPFNWDCEFIRLHFGHN RKKHLNYTEFTQFLQELQLE HARQAFALKDKSKSGMISGL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SLC25A12 (NP_003696.2). |
Additional Info
| Tissue Specificity | Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney. |
| Function | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA). |
| Protein Name | Electrogenic Aspartate/Glutamate Antiporter Slc25a12 - MitochondrialAraceli HiperlargaAralarAralar1Mitochondrial Aspartate Glutamate Carrier 1Solute Carrier Family 25 Member 12 |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-8963693Reactome: R-HSA-9856872 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Electrogenic Aspartate/Glutamate Antiporter Slc25a12 - Mitochondrial antibodyAnti-Araceli Hiperlarga antibodyAnti-Aralar antibodyAnti-Aralar1 antibodyAnti-Mitochondrial Aspartate Glutamate Carrier 1 antibodyAnti-Solute Carrier Family 25 Member 12 antibodyAnti-SLC25A12 antibodyAnti-AGC1 antibodyAnti-ARALAR1 antibody |
Information sourced from Uniprot.org