Anti-SP140 antibody (1-180) (STJ119692)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SP140 (1-180) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SP140 |
| Gene ID | 11262 |
| Uniprot ID | SP140_HUMAN |
| Immunogen Region | 1-180 |
| Immunogen Sequence | MAQQGQQGQMASGDSNLNFR MVAEIQNVEGQNLQEQVCPE PIFRFFRENKVEIASAITRP FPFLMGLRDRSFISEQMYEH FQEAFRNLVPVTRVMYCVLS ELEKTFGWSHLEALFSRINL MAYPDLNEIYRSFQNVCYEH SPLQMNNVNDLEDRPRLLPY GKQENSNACHEMDDIAVPQE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-180 of human SP140 (NP_001265380). |
Additional Info
| Tissue Specificity | High levels in spleen and peripheral blood leukocytes, much lower levels in tonsils, thymus, prostate, ovary, small intestine, and colon. Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not detected in brain, liver and muscle. |
| Post Translational Modifications | Phosphorylation at Thr-726 promotes binding of PIN1 and subsequent isomerization of Pro-727. |
| Function | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails. |
| Protein Name | Nuclear Body Protein Sp140Lymphoid-Restricted Homolog Of Sp100Lysp100Nuclear Autoantigen Sp-140Speckled 140 Kda |
| Database Links | |
| Cellular Localisation | NucleusPml BodyCytoplasmLocalized To Nuclear Structures Termed LandsFor Lysp100-Associated Nuclear DomainsLands Are GlobularElectron-Dense Structures Most Often Found In The NucleoplasmBut Also Found At The Nuclear Membrane And In The CytoplasmSuggesting That These Structures May Traffic Between The Cytoplasm And The NucleusAlso Colocalizes With Pml In A Subset Of Pml Nuclear Bodies |
| Alternative Antibody Names | Anti-Nuclear Body Protein Sp140 antibodyAnti-Lymphoid-Restricted Homolog Of Sp100 antibodyAnti-Lysp100 antibodyAnti-Nuclear Autoantigen Sp-140 antibodyAnti-Speckled 140 Kda antibodyAnti-SP140 antibodyAnti-LYSP100 antibody |
Information sourced from Uniprot.org