Anti-SLC26A11 antibody (500-600) (STJ119420)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC26A11 (500-600) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC26A11 |
| Gene ID | 284129 |
| Uniprot ID | S2611_HUMAN |
| Immunogen Region | 500-600 |
| Immunogen Sequence | EILSRALEVSPPRCLVLECT HVCSIDYTVVLGLGELLQDF QKQGVALAFVGLQVPVLRVL LSADLKGFQYFSTLEEAEKH LRQEPGTQPYNIREDSILDQ K |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SLC26A11 (NP_001159819.1). |
Additional Info
| Tissue Specificity | Detected in all tissues tested with highest expression observed in brain, kidney, HEVEC and placenta and lowest in pancreas, skeletal muscle, liver, lung and heart. |
| Function | Sodium-independent anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. Exhibits sodium-independent sulfate anion transporter activity that may cooperate with SLC26A2 to mediate DIDS-sensitive sulfate uptake into high endothelial venules endothelial cells (HEVEC). In the kidney, mediates chloride-bicarbonate exchange, facilitating V-ATPase-mediated acid secretion. May function as a chloride channel, playing an important role in moderating chloride homeostasis and neuronal activity in the cerebellum. |
| Protein Name | Sodium-Independent Sulfate Anion TransporterSolute Carrier Family 26 Member 11 |
| Database Links | Reactome: R-HSA-427601 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLysosome MembraneApical Cell MembraneBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Sodium-Independent Sulfate Anion Transporter antibodyAnti-Solute Carrier Family 26 Member 11 antibodyAnti-SLC26A11 antibody |
Information sourced from Uniprot.org