Anti-SLC25A27 antibody (258-275) (STJ115776)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC25A27 (258-275) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC25A27 |
| Gene ID | 9481 |
| Uniprot ID | UCP4_HUMAN |
| Immunogen Region | 258-275 |
| Immunogen Sequence | ALVNMGDLTTYDTVKHYLVL NTPLEDNIMTHGLSSLCSGL VASILGTPADVIKSRIMNQP RDKQGRGLLYKSSTDCLIQA VQGEGFMSLYKGFLPSWLRM TPWSMVFWLTYEKIREMSGV SPF |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 201-300 of human SLC25A27 (NP_004268.3). |
Additional Info
| Tissue Specificity | Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal cord, corpus callosum and substantia nigra. |
| Function | Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated. |
| Protein Name | Mitochondrial Uncoupling Protein 4Ucp 4Solute Carrier Family 25 Member 27 |
| Database Links | Reactome: R-HSA-167826 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane ProteinLocalizes To Neuronal Cell Body And ProcessesWithin Mitochondrial Inner MembraneIt Is Mainly Observed In The Inner Boundary Membrane Locally Separated From F(1)F(0) Atp SynthaseWhich Is Preferentially Localized In Cristae |
| Alternative Antibody Names | Anti-Mitochondrial Uncoupling Protein 4 antibodyAnti-Ucp 4 antibodyAnti-Solute Carrier Family 25 Member 27 antibodyAnti-SLC25A27 antibodyAnti-UCP4 antibodyAnti-UNQ772 antibodyAnti-PRO1566 antibody |
Information sourced from Uniprot.org