| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC25A27 (258-275) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC25A27 |
| Gene ID: |
9481 |
| Uniprot ID: |
UCP4_HUMAN |
| Immunogen Region: |
258-275 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 258-275 of human SLC25A27 (NP_004268.3). |
| Immunogen Sequence: |
NQPRDKQGRGLLYKSSTD |
| Tissue Specificity | Found in adult and fetal brain. Present in most of the brain tissues, with low levels in spinal chord, corpus callosum and substantia nigra. |
| Function | Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated. |
| Protein Name | Mitochondrial Uncoupling Protein 4Ucp 4Solute Carrier Family 25 Member 27 |
| Database Links | Reactome: R-HSA-167826Reactome: R-HSA-167827 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane ProteinLocalizes To Neuronal Cell Body And ProcessesWithin Mitochondrial Inner MembraneIt Is Mainly Observed In The Inner Boundary Membrane Locally Separated From F(1)F(0) Atp SynthaseWhich Is Preferentially Localized In Cristae |
| Alternative Antibody Names | Anti-Mitochondrial Uncoupling Protein 4 antibodyAnti-Ucp 4 antibodyAnti-Solute Carrier Family 25 Member 27 antibodyAnti-SLC25A27 antibodyAnti-UCP4 antibodyAnti-UNQ772 antibodyAnti-PRO1566 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
