| Host: | Rabbit |
| Applications: | IHC-P/IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SLC18A3 |
| Gene ID: | 6572 |
| Uniprot ID: | VACHT_HUMAN |
| Immunogen Region: | 473-532 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 473-532 of human SLC18A3 (NP_003046.2). |
| Immunogen Sequence: | GLLTRSRSERDVLLDEPPQG LYDAVRLRERPVSGQDGEPR SPPGPFDACEDDYNYYYTRS |
| Tissue Specificity | Peripheral and central cholinergic nervous systems. |
| Function | Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis. Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern. Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation. Can transport serotonin. |
| Protein Name | Vesicular Acetylcholine Transporter Vacht Solute Carrier Family 18 Member 3 |
| Database Links | Reactome: R-HSA-264642 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 |
| Cellular Localisation | Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Vesicular Acetylcholine Transporter antibody Anti-Vacht antibody Anti-Solute Carrier Family 18 Member 3 antibody Anti-SLC18A3 antibody Anti-VACHT antibody |
Information sourced from Uniprot.org