| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-ABCD2 (460-473) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.5-2µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
ABCD2 |
| Gene ID: |
225 |
| Uniprot ID: |
ABCD2_HUMAN |
| Immunogen Region: |
460-473 |
| Accession Number: |
NP_005155.1 |
| Specificity: |
No cross-reactivity expected with ABCD1. |
| Immunogen Sequence: |
PLSDTLAIKGKVID |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Like ABCD1 seems to have fatty acyl-CoA thioesterase (ACOT) and ATPase activities, according to this model, VLCFA-CoA as free VLCFA is transpoted in an ATP-dependent manner into peroxisomes after the hydrolysis of VLCFA-CoA mediated by the ACOT activity of ABCD2 (Probable). Shows overlapping substrate specificities with ABCD1 toward saturated fatty acids (FA) and monounsaturated FA (MUFA) but has a distinct substrate preference for shorter VLCFA (C22:0) and polyunsaturated fatty acid (PUFA) such as C22:6-CoA and C24:6-CoA (in vitro). Thus, may play a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation. |
| Protein Name | Atp-Binding Cassette Sub-Family D Member 2Adrenoleukodystrophy-Like 1Adrenoleukodystrophy-Related ProteinHaldr |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family D Member 2 antibodyAnti-Adrenoleukodystrophy-Like 1 antibodyAnti-Adrenoleukodystrophy-Related Protein antibodyAnti-Haldr antibodyAnti-ABCD2 antibodyAnti-ALD1 antibodyAnti-ALDL1 antibodyAnti-ALDR antibodyAnti-ALDRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
