Anti-RTN4R antibody (244-473) (STJ28410)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RTN4R (244-473) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:100-1:500IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RTN4R |
| Gene ID | 65078 |
| Uniprot ID | RTN4R_HUMAN |
| Immunogen Region | 244-473 |
| Immunogen Sequence | EALAPLRALQYLRLNDNPWV CDCRARPLWAWLQKFRGSSS EVPCSLPQRLAGRDLKRLAA NDLQGCAVATGPYHPIWTGR ATDEEPLGLPKCCQPDAADK ASVLEPGRPASAGNALKGRV PPGDSPPGNGSGPRHINDSP FGTLPGSAEPPLTAVRPEGS EPPGFPTSGPRRRPGCSRKN RTRSHCRLGQAGSGGGGTGD SEGSGALPSLTCSLTPLGLA LVLWTVLGPC |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 244-473 of human NOGO Receptor 1 (RTN4R) (NP_075380.1). |
Additional Info
| Tissue Specificity | Widespread in the brain but highest levels in the gray matter. Low levels in heart and kidney.not expressed in oligodendrocytes (white matter). |
| Post Translational Modifications | N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains. |
| Function | Receptor for RTN4, OMG and MAG. Functions as a receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as a receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. Mediates axonal growth inhibition. Plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis.protection against apoptosis is probably mediated via interaction with MAG. Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. |
| Protein Name | Reticulon-4 ReceptorNogo ReceptorNgrNogo-66 Receptor |
| Database Links | Reactome: R-HSA-193634 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftCell ProjectionDendriteAxonPerikaryonDetected Along Dendrites And AxonsClose To SynapsesBut Clearly Excluded From Synapses |
| Alternative Antibody Names | Anti-Reticulon-4 Receptor antibodyAnti-Nogo Receptor antibodyAnti-Ngr antibodyAnti-Nogo-66 Receptor antibodyAnti-RTN4R antibodyAnti-NOGOR antibodyAnti-UNQ330 antibodyAnti-PRO526 antibody |
Information sourced from Uniprot.org