Anti-SETD6 antibody (301-473) (STJ29385)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SETD6 (301-473) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SETD6 |
| Gene ID | 79918 |
| Uniprot ID | SETD6_HUMAN |
| Immunogen Region | 301-473 |
| Immunogen Sequence | EPYPDNTDDTADIQMVTVRE AALQGTKTEAERHLVYERWD FLCKLEMVGEEGAFVIGREE VLTEEELTTTLKVLCMPAEE FRELKDQDGGGDDKREEGSL TITNIPKLKASWRQLLQNSV LLTLQTYATDLKTDQGLLSN KEVYAKLSWREQQALQVRYG QKMILHQLLELTS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 301-473 of human SETD6 (NP_001153777.1). |
Additional Info
| Post Translational Modifications | Automethylated.Lys-39 and Lys-179 serve as the major automethylation sites. |
| Function | Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal. Methylates PAK4. |
| Protein Name | N-Lysine Methyltransferase Setd6Set Domain-Containing Protein 6 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-N-Lysine Methyltransferase Setd6 antibodyAnti-Set Domain-Containing Protein 6 antibodyAnti-SETD6 antibody |
Information sourced from Uniprot.org