Anti-SLC18A3 antibody (473-532) (STJ118508)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SLC18A3 (473-532) antibody for use in IHC-P, IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC18A3 |
| Gene ID | 6572 |
| Uniprot ID | VACHT_HUMAN |
| Immunogen Region | 473-532 |
| Immunogen Sequence | GLLTRSRSERDVLLDEPPQG LYDAVRLRERPVSGQDGEPR SPPGPFDACEDDYNYYYTRS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 473-532 of human SLC18A3 (NP_003046.2). |
Additional Info
| Tissue Specificity | Peripheral and central cholinergic nervous systems. |
| Function | Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis. Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern. Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation. Can transport serotonin. |
| Protein Name | Vesicular Acetylcholine TransporterVachtSolute Carrier Family 18 Member 3 |
| Database Links | Reactome: R-HSA-264642Reactome: R-HSA-8856825Reactome: R-HSA-8856828 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Vesicular Acetylcholine Transporter antibodyAnti-Vacht antibodyAnti-Solute Carrier Family 18 Member 3 antibodyAnti-SLC18A3 antibodyAnti-VACHT antibody |
Information sourced from Uniprot.org