| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SGPL1 (60-390) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SGPL1 |
| Gene ID: |
8879 |
| Uniprot ID: |
SGPL1_HUMAN |
| Immunogen Region: |
60-390 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-390 of human SGPL1 (NP_003892.2). |
| Immunogen Sequence: |
VFQPESLWSRFKKKCFKLTR KMPIIGRKIQDKLNKTKDDI SKNMSFLKVDKEYVKALPSQ GLSSSAVLEKLKEYSSMDAF WQEGRASGTVYSGEEKLTEL LVKAYGDFAWSNPLHPDIFP GLRKIEAEIVRIACSLFNGG PDSCGCVTSGGTESILMACK AYRDLAFEKGIKTPEIVAPQ SAHAAFNKAASYFGMKIVRV PLTKMMEVDVRAMRRAISRN TAMLVCSTPQFPHGVIDPV |
| Tissue Specificity | Ubiquitously expressed. Expressed in fetal and adult adrenal gland (at protein level). |
| Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance. |
| Protein Name | Sphingosine-1-Phosphate Lyase 1S1plSp-Lyase 1Spl 1HsplSphingosine-1-Phosphate Aldolase |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iii Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Sphingosine-1-Phosphate Lyase 1 antibodyAnti-S1pl antibodyAnti-Sp-Lyase 1 antibodyAnti-Spl 1 antibodyAnti-Hspl antibodyAnti-Sphingosine-1-Phosphate Aldolase antibodyAnti-SGPL1 antibodyAnti-KIAA1252 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
