| Short Description : | Rabbit polyclonal SGPL1 (60-390) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SGPL1 |
| Gene ID: | 8879 |
| Uniprot ID: | SGPL1_HUMAN |
| Immunogen Region: | 60-390 |
| Immunogen Sequence: | VFQPESLWSRFKKKCFKLTR KMPIIGRKIQDKLNKTKDDI SKNMSFLKVDKEYVKALPSQ GLSSSAVLEKLKEYSSMDAF WQEGRASGTVYSGEEKLTEL LVKAYGDFAWSNPLHPDIFP GLRKIEAEIVRIACSLFNGG PDSCGCVTSGGTESILMACK AYRDLAFEKGIKTPEIVAPQ SAHAAFNKAASYFGMKIVRV PLTKMMEVDVRAMRRAISRN TAMLVCSTPQFPHGVIDPV |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-390 of human SGPL1 (NP_003892.2). |
| Tissue Specificity | Ubiquitously expressed. Expressed in fetal and adult adrenal gland (at protein level). |
| Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance. |
| Protein Name | Sphingosine-1-Phosphate Lyase 1S1plSp-Lyase 1Spl 1HsplSphingosine-1-Phosphate Aldolase |
| Database Links | Reactome: R-HSA-9845614 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iii Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Sphingosine-1-Phosphate Lyase 1 antibodyAnti-S1pl antibodyAnti-Sp-Lyase 1 antibodyAnti-Spl 1 antibodyAnti-Hspl antibodyAnti-Sphingosine-1-Phosphate Aldolase antibodyAnti-SGPL1 antibodyAnti-KIAA1252 antibody |
Information sourced from Uniprot.org
