Name: Anti-SGPL1 antibody (393-443 aa) (STJ193618)
SKU: STJ193618
Availability: InStock

Anti-SGPL1 antibody (393-443 aa) (STJ193618)

SKU:

STJ193618

€58.80 - €313.20

Short Description :	Rabbit polyclonal anti-Sphingosine-1-phosphate lyase 1 (393-443 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:	WB
Host:	Rabbit
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality :	Polyclonal
Isotype:	IgG
Conjugation:	Unconjugated
Concentration:	1 mg/mL
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range:	WB 1:500-2000
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SGPL1
Gene ID:	8879
Uniprot ID:	SGPL1_HUMAN
Immunogen:	Synthesized peptide derived from the human SGPL1 at the amino acid range 393-443
Immunogen Region:	393-443 aa
Specificity:	This antibody detects endogenous levels of SGPL1 at Human/Mouse/Rat

Function	Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance.
Protein Name	Sphingosine-1-Phosphate Lyase 1 S1pl Sp-Lyase 1 Spl 1 Hspl Sphingosine-1-Phosphate Aldolase
Database Links	Reactome: R-HSA-9845614
Cellular Localisation	Endoplasmic Reticulum Membrane Single-Pass Type Iii Membrane Protein Cytoplasmic Side
Alternative Antibody Names	Anti-Sphingosine-1-Phosphate Lyase 1 antibody Anti-S1pl antibody Anti-Sp-Lyase 1 antibody Anti-Spl 1 antibody Anti-Hspl antibody Anti-Sphingosine-1-Phosphate Aldolase antibody Anti-SGPL1 antibody Anti-KIAA1252 antibody

Information sourced from Uniprot.org

Anti-SGPL1 antibody (393-443 aa) (STJ193618)

General Information

Model	Name	Host	Clonality	Reactivity	Application
STJ196044	Anti-ABR antibody (393-443 aa) (STJ196044)	Rabbit	Polyclonal	Human/Mouse	WB
STJ195424	Anti-ZNF860 antibody (393-443 aa) (STJ195424)	Rabbit	Polyclonal	Human/Rat/Mouse	WB
STJ194375	Anti-KBTBD4 antibody (393-443 aa) (STJ194375)	Rabbit	Polyclonal	Human/Mouse	WB
STJ195702	Anti-SIDT2 antibody (393-443 aa) (STJ195702)	Rabbit	Polyclonal	Human/Mouse/Rat	WB/ELISA/IHC
STJ11107092	Anti-SGPL1 antibody (301-400 aa) (STJ11107092)	Rabbit	Polyclonal	Human/Mouse/Rat	IHC-P/IF/ICC/ELISA