| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Sphingosine-1-phosphate lyase 1 (393-443 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SGPL1 |
| Gene ID: |
8879 |
| Uniprot ID: |
SGPL1_HUMAN |
| Immunogen Region: |
393-443 aa |
| Specificity: |
This antibody detects endogenous levels of SGPL1 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human SGPL1 at the amino acid range 393-443 |
| Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance. |
| Protein Name | Sphingosine-1-Phosphate Lyase 1S1plSp-Lyase 1Spl 1HsplSphingosine-1-Phosphate Aldolase |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iii Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Sphingosine-1-Phosphate Lyase 1 antibodyAnti-S1pl antibodyAnti-Sp-Lyase 1 antibodyAnti-Spl 1 antibodyAnti-Hspl antibodyAnti-Sphingosine-1-Phosphate Aldolase antibodyAnti-SGPL1 antibodyAnti-KIAA1252 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
