Anti-SGPL1 antibody (393-443 aa) (STJ193618)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SGPL1 at the amino acid range 393-443
General Information
| Short Description | Rabbit polyclonal anti-Sphingosine-1-phosphate lyase 1 (393-443 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SGPL1 |
| Gene ID | 8879 |
| Uniprot ID | SGPL1_HUMAN |
| Immunogen | Synthesized peptide derived from the human SGPL1 at the amino acid range 393-443 |
| Immunogen Region | 393-443 aa |
| Specificity | This antibody detects endogenous levels of SGPL1 at Human/Mouse/Rat |
Additional Info
| Function | Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance. |
| Protein Name | Sphingosine-1-Phosphate Lyase 1S1plSp-Lyase 1Spl 1HsplSphingosine-1-Phosphate Aldolase |
| Database Links | Reactome: R-HSA-9845614 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iii Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Sphingosine-1-Phosphate Lyase 1 antibodyAnti-S1pl antibodyAnti-Sp-Lyase 1 antibodyAnti-Spl 1 antibodyAnti-Hspl antibodyAnti-Sphingosine-1-Phosphate Aldolase antibodyAnti-SGPL1 antibodyAnti-KIAA1252 antibody |
Information sourced from Uniprot.org