Anti-SERCA1/ATP2A1 antibody (900-1001) [S4MR] (STJ11103064)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal SERCA1/ATP2A1 (900-1001) antibody for use in WB, IF, ICC and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ATP2A1 |
| Gene ID | 487 |
| Uniprot ID | AT2A1_HUMAN |
| Immunogen Region | 900-1001 |
| Immunogen Sequence | ALSVLVTIEMCNALNSLSEN QSLLRMPPWVNIWLLGSICL SMSLHFLILYVDPLPMIFKL RALDLTQWLMVLKISLPVIG LDEILKFVARNYLEDPEDER RK |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 900-1001 of human SERCA1/ATP2A1 (O14983). |
Additional Info
| Tissue Specificity | Skeletal muscle, fast twitch muscle (type II) fibers. |
| Function | Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. |
| Protein Name | Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1Serca1Sr Ca(2+-Atpase 1Calcium Pump 1Calcium-Transporting Atpase Sarcoplasmic Reticulum Type - Fast Twitch Skeletal Muscle IsoformEndoplasmic Reticulum Class 1/2 Ca(2+ Atpase |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-418359Reactome: R-HSA-5578775Reactome: R-HSA-936837 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinSarcoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Sarcoplasmic/Endoplasmic Reticulum Calcium Atpase 1 antibodyAnti-Serca1 antibodyAnti-Sr Ca(2+-Atpase 1 antibodyAnti-Calcium Pump 1 antibodyAnti-Calcium-Transporting Atpase Sarcoplasmic Reticulum Type - Fast Twitch Skeletal Muscle Isoform antibodyAnti-Endoplasmic Reticulum Class 1/2 Ca(2+ Atpase antibodyAnti-ATP2A1 antibody |
Information sourced from Uniprot.org