Anti-RRAD antibody (36-48) (STJ72757)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-RRAD (36-48) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 37kDa band observed in Mouse Heart lysates and no 37kDa in the KO lysates (calculated MW of 33.2kDa according to mouse NP_062636.2 and human NP_004156.1). There is some non-spec |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | RRAD |
| Gene ID | 6236 |
| Uniprot ID | RAD_HUMAN |
| Accession Number | NP_004156.1 |
| Immunogen Region | 36-48 |
| Immunogen Sequence | HRRSMPVDERDLQ |
| Specificity | Reported variants represent identical protein: NP_004156.1, NP_001122322.1 |
Additional Info
| Function | May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. |
| Protein Name | Gtp-Binding Protein RadRad1Ras Associated With Diabetes |
| Database Links | Reactome: R-HSA-9031628 |
| Cellular Localisation | Cell Membrane |
| Alternative Antibody Names | Anti-Gtp-Binding Protein Rad antibodyAnti-Rad1 antibodyAnti-Ras Associated With Diabetes antibodyAnti-RRAD antibodyAnti-RAD antibody |
Information sourced from Uniprot.org