| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RNASEH1 |
| Gene ID: | 246243 |
| Uniprot ID: | RNH1_HUMAN |
| Immunogen Region: | 1-286 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human RNASEH1 (NP_002927.2). |
| Immunogen Sequence: | MSWLLFLAHRVALAALPCRR GSRGFGMFYAVRRGRKTGVF LTWNECRAQVDRFPAARFKK FATEDEAWAFVRKSASPEVS EGHENQHGQESEAKASKRLR EPLDGDGHESAEPYAKHMKP SVEPAPPVSRDTFSYMGDFV VVYTDGCCSSNGRRRPRAGI GVYWGPGHPLNVGIRLPGRQ TNQRAEIHAACKAIEQAKTQ NINKLVLYTDSMFTINGITN WVQGWKKNGWKTSAGKEVI |
| Tissue Specificity | Ubiquitous. |
| Function | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II. |
| Protein Name | Ribonuclease H1Rnase H1Ribonuclease H Type Ii |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ribonuclease H1 antibodyAnti-Rnase H1 antibodyAnti-Ribonuclease H Type Ii antibodyAnti-RNASEH1 antibodyAnti-RNH1 antibody |
Information sourced from Uniprot.org