| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CAPZA1 (1-286) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CAPZA1 |
| Gene ID: |
829 |
| Uniprot ID: |
CAZA1_HUMAN |
| Immunogen Region: |
1-286 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human CAPZA1 (NP_006126.1). |
| Immunogen Sequence: |
MADFDDRVSDEEKVRIAAKF ITHAPPGEFNEVFNDVRLLL NNDNLLREGAAHAFAQYNMD QFTPVKIEGYEDQVLITEHG DLGNSRFLDPRNKISFKFDH LRKEASDPQPEEADGGLKSW RESCDSALRAYVKDHYSNGF CTVYAKTIDGQQTIIACIES HQFQPKNFWNGRWRSEWKFT ITPPTAQVVGVLKIQVHYYE DGNVQLVSHKDVQDSLTVSN EAQTAKEFIKIIENAENEY |
| Function | F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. |
| Protein Name | F-Actin-Capping Protein Subunit Alpha-1Capz Alpha-1 |
| Database Links | Reactome: R-HSA-2132295Reactome: R-HSA-3371497Reactome: R-HSA-6807878Reactome: R-HSA-6811436Reactome: R-HSA-879415Reactome: R-HSA-8950505Reactome: R-HSA-9662360Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-F-Actin-Capping Protein Subunit Alpha-1 antibodyAnti-Capz Alpha-1 antibodyAnti-CAPZA1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
