Anti-RNASEH1 antibody (1-286) (STJ111576)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RNASEH1 (1-286) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNASEH1 |
| Gene ID | 246243 |
| Uniprot ID | RNH1_HUMAN |
| Immunogen Region | 1-286 |
| Immunogen Sequence | MSWLLFLAHRVALAALPCRR GSRGFGMFYAVRRGRKTGVF LTWNECRAQVDRFPAARFKK FATEDEAWAFVRKSASPEVS EGHENQHGQESEAKASKRLR EPLDGDGHESAEPYAKHMKP SVEPAPPVSRDTFSYMGDFV VVYTDGCCSSNGRRRPRAGI GVYWGPGHPLNVGIRLPGRQ TNQRAEIHAACKAIEQAKTQ NINKLVLYTDSMFTINGITN WVQGWKKNGWKTSAGKEVI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-286 of human RNASEH1 (NP_002927.2). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II. |
| Protein Name | Ribonuclease H1Rnase H1Ribonuclease H Type Ii |
| Database Links | Reactome: R-HSA-9913635 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ribonuclease H1 antibodyAnti-Rnase H1 antibodyAnti-Ribonuclease H Type Ii antibodyAnti-RNASEH1 antibodyAnti-RNH1 antibody |
Information sourced from Uniprot.org