| Short Description : | Rabbit polyclonal PTP4A3 (1-148) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTP4A3 |
| Gene ID: | 11156 |
| Uniprot ID: | TP4A3_HUMAN |
| Immunogen Region: | 1-148 |
| Immunogen Sequence: | MARMNRPAPVEVSYKHMRFL ITHNPTNATLSTFIEDLKKY GATTVVRVCEVTYDKTPLEK DGITVVDWPFDDGAPPPGKV VEDWLSLVKAKFCEAPGSCV AVHCVAGLGRKRRGAINSKQ LTYLEKYRPKQRLRFKDPHT HKTRCCVM |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human PTP4A3 (NP_009010.2). |
| Tissue Specificity | Mainly expressed in cardiomyocytes and skeletal muscle.also found in pancreas. Consistently overexpressed in colon cancer metastasis. |
| Post Translational Modifications | Farnesylated. Farnesylation is required for membrane targeting. |
| Function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. |
| Protein Name | Protein Tyrosine Phosphatase Type Iva 3Prl-RProtein-Tyrosine Phosphatase 4a3Protein-Tyrosine Phosphatase Of Regenerating Liver 3Prl-3 |
| Database Links | |
| Cellular Localisation | Cell MembraneEarly Endosome |
| Alternative Antibody Names | Anti-Protein Tyrosine Phosphatase Type Iva 3 antibodyAnti-Prl-R antibodyAnti-Protein-Tyrosine Phosphatase 4a3 antibodyAnti-Protein-Tyrosine Phosphatase Of Regenerating Liver 3 antibodyAnti-Prl-3 antibodyAnti-PTP4A3 antibodyAnti-PRL3 antibody |
Information sourced from Uniprot.org
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