| Tissue Specificity | Mainly expressed in cardiomyocytes and skeletal muscle.also found in pancreas. Consistently overexpressed in colon cancer metastasis. |
| Post Translational Modifications | Farnesylated. Farnesylation is required for membrane targeting. |
| Function | Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. |
| Protein Name | Protein Tyrosine Phosphatase Type Iva 3Prl-RProtein-Tyrosine Phosphatase 4a3Protein-Tyrosine Phosphatase Of Regenerating Liver 3Prl-3 |
| Cellular Localisation | Cell MembraneEarly Endosome |
| Alternative Antibody Names | Anti-Protein Tyrosine Phosphatase Type Iva 3 antibodyAnti-Prl-R antibodyAnti-Protein-Tyrosine Phosphatase 4a3 antibodyAnti-Protein-Tyrosine Phosphatase Of Regenerating Liver 3 antibodyAnti-Prl-3 antibodyAnti-PTP4A3 antibodyAnti-PRL3 antibody |
Information sourced from Uniprot.org
![Immunohistochemistry analysis of EDF1 in paraffin-embedded mouse lung using [KO Validated] EDF1 Rabbit polyclonal antibody (STJ23470) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/99544/384668/STJ23470_1__14722.1713153436.jpg?c=1 "Immunohistochemistry analysis of EDF1 in paraffin-embedded mouse lung using [KO Validated] EDF1 Rabbit polyclonal antibody (STJ23470) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.")
