Immunohistochemistry analysis of paraffin-embedded human gastric cancer using PTP4A3 antibody (STJ25221) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-PTP4A3 antibody (1-148) (STJ25221)

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STJ25221
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:100
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTP4A3
Gene ID: 11156
Uniprot ID: TP4A3_HUMAN
Immunogen Region: 1-148
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-148 of human PTP4A3 (NP_009010.2).
Immunogen Sequence: MARMNRPAPVEVSYKHMRFL ITHNPTNATLSTFIEDLKKY GATTVVRVCEVTYDKTPLEK DGITVVDWPFDDGAPPPGKV VEDWLSLVKAKFCEAPGSCV AVHCVAGLGRKRRGAINSKQ LTYLEKYRPKQRLRFKDPHT HKTRCCVM
Tissue Specificity Mainly expressed in cardiomyocytes and skeletal muscle.also found in pancreas. Consistently overexpressed in colon cancer metastasis.
Post Translational Modifications Farnesylated. Farnesylation is required for membrane targeting.
Function Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Protein Name Protein Tyrosine Phosphatase Type Iva 3
Prl-R
Protein-Tyrosine Phosphatase 4a3
Protein-Tyrosine Phosphatase Of Regenerating Liver 3
Prl-3
Cellular Localisation Cell Membrane
Early Endosome
Alternative Antibody Names Anti-Protein Tyrosine Phosphatase Type Iva 3 antibody
Anti-Prl-R antibody
Anti-Protein-Tyrosine Phosphatase 4a3 antibody
Anti-Protein-Tyrosine Phosphatase Of Regenerating Liver 3 antibody
Anti-Prl-3 antibody
Anti-PTP4A3 antibody
Anti-PRL3 antibody

Information sourced from Uniprot.org

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