| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PIK3R2 (1-85) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PIK3R2 |
| Gene ID: |
5296 |
| Uniprot ID: |
P85B_HUMAN |
| Immunogen Region: |
1-85 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-85 of human PI3 Kinase p85 beta (NP_005018.1). |
| Immunogen Sequence: |
MAGPEGFQYRALYPFRRERP EDLELLPGDVLVVSRAALQA LGVAEGGERCPQSVGWMPGL NERTRQRGDFPGTYVEFLGP VALAR |
| Post Translational Modifications | Phosphorylated in response to signaling from activated receptor-type protein kinases. Dephosphorylated by PTPRJ. Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination. Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2. |
| Function | Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. |
| Protein Name | Phosphatidylinositol 3-Kinase Regulatory Subunit BetaPi3-Kinase Regulatory Subunit BetaPi3k Regulatory Subunit BetaPtdins-3-Kinase Regulatory Subunit BetaPhosphatidylinositol 3-Kinase 85 Kda Regulatory Subunit BetaPi3-Kinase Subunit P85-BetaPtdins-3-Kinase Regulatory Subunit P85-Beta |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-112399Reactome: R-HSA-114604Reactome: R-HSA-1257604Reactome: R-HSA-1266695Reactome: R-HSA-1433557Reactome: R-HSA-1660499Reactome: R-HSA-186763Reactome: R-HSA-198203Reactome: R-HSA-201556Reactome: R-HSA-202424Reactome: R-HSA-2029485Reactome: R-HSA-210993Reactome: R-HSA-2219530Reactome: R-HSA-2424491Reactome: R-HSA-2730905Reactome: R-HSA-373753Reactome: R-HSA-388841Reactome: R-HSA-389357Reactome: R-HSA-416476Reactome: R-HSA-4420097Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-6811558Reactome: R-HSA-8853659Reactome: R-HSA-8980692Reactome: R-HSA-9009391Reactome: R-HSA-9013026Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013405Reactome: R-HSA-9013409Reactome: R-HSA-9013420Reactome: R-HSA-9013423Reactome: R-HSA-9035034Reactome: R-HSA-912526Reactome: R-HSA-912631Reactome: R-HSA-9670439Reactome: R-HSA-9673767Reactome: R-HSA-9673770Reactome: R-HSA-9696264Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Alternative Antibody Names | Anti-Phosphatidylinositol 3-Kinase Regulatory Subunit Beta antibodyAnti-Pi3-Kinase Regulatory Subunit Beta antibodyAnti-Pi3k Regulatory Subunit Beta antibodyAnti-Ptdins-3-Kinase Regulatory Subunit Beta antibodyAnti-Phosphatidylinositol 3-Kinase 85 Kda Regulatory Subunit Beta antibodyAnti-Pi3-Kinase Subunit P85-Beta antibodyAnti-Ptdins-3-Kinase Regulatory Subunit P85-Beta antibodyAnti-PIK3R2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
