| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PIK3R2 |
| Gene ID: | 5296 |
| Uniprot ID: | P85B_HUMAN |
| Immunogen Region: | 1-85 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-85 of human PI3 Kinase p85 beta (NP_005018.1). |
| Immunogen Sequence: | MAGPEGFQYRALYPFRRERP EDLELLPGDVLVVSRAALQA LGVAEGGERCPQSVGWMPGL NERTRQRGDFPGTYVEFLGP VALAR |
| Post Translational Modifications | Phosphorylated in response to signaling from activated receptor-type protein kinases. Dephosphorylated by PTPRJ. Dephosphorylated at Tyr-655 by PTPN13. Phosphorylation of Tyr-655 impairs while its dephosphorylation promotes interaction with FBXL2 and SCF(FBXL2)-mediated polyubiquitination. Ubiquitinated. Polyubiquitination by the SCF(FBXL2) complex probably promotes proteasomal degradation of PIK3R2. |
| Function | Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. |
| Protein Name | Phosphatidylinositol 3-Kinase Regulatory Subunit Beta Pi3-Kinase Regulatory Subunit Beta Pi3k Regulatory Subunit Beta Ptdins-3-Kinase Regulatory Subunit Beta Phosphatidylinositol 3-Kinase 85 Kda Regulatory Subunit Beta Pi3-Kinase Subunit P85-Beta Ptdins-3-Kinase Regulatory Subunit P85-Beta |
| Database Links | Reactome: R-HSA-109704 Reactome: R-HSA-112399 Reactome: R-HSA-114604 Reactome: R-HSA-1257604 Reactome: R-HSA-1266695 Reactome: R-HSA-1433557 Reactome: R-HSA-1660499 Reactome: R-HSA-186763 Reactome: R-HSA-198203 Reactome: R-HSA-201556 Reactome: R-HSA-202424 Reactome: R-HSA-2029485 Reactome: R-HSA-210993 Reactome: R-HSA-2219530 Reactome: R-HSA-2424491 Reactome: R-HSA-2730905 Reactome: R-HSA-373753 Reactome: R-HSA-388841 Reactome: R-HSA-389357 Reactome: R-HSA-416476 Reactome: R-HSA-4420097 Reactome: R-HSA-512988 Reactome: R-HSA-5673001 Reactome: R-HSA-6811558 Reactome: R-HSA-8853659 Reactome: R-HSA-8980692 Reactome: R-HSA-9009391 Reactome: R-HSA-9013026 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013405 Reactome: R-HSA-9013409 Reactome: R-HSA-9013420 Reactome: R-HSA-9013423 Reactome: R-HSA-9035034 Reactome: R-HSA-912526 Reactome: R-HSA-912631 Reactome: R-HSA-9670439 Reactome: R-HSA-9673767 Reactome: R-HSA-9673770 Reactome: R-HSA-9696264 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273 Reactome: R-HSA-9725370 Reactome: R-HSA-9842640 Reactome: R-HSA-9842663 |
| Alternative Antibody Names | Anti-Phosphatidylinositol 3-Kinase Regulatory Subunit Beta antibody Anti-Pi3-Kinase Regulatory Subunit Beta antibody Anti-Pi3k Regulatory Subunit Beta antibody Anti-Ptdins-3-Kinase Regulatory Subunit Beta antibody Anti-Phosphatidylinositol 3-Kinase 85 Kda Regulatory Subunit Beta antibody Anti-Pi3-Kinase Subunit P85-Beta antibody Anti-Ptdins-3-Kinase Regulatory Subunit P85-Beta antibody Anti-PIK3R2 antibody |
Information sourced from Uniprot.org