| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPRA |
| Gene ID: | 5786 |
| Uniprot ID: | PTPRA_HUMAN |
| Specificity: | A synthetic phosphorylated peptide around Y789 of human PTPRA (NP_543030.1). |
| Immunogen Sequence: | SDYAN |
| Post Translational Modifications | Integrin binding to extracellular matrix induces phosphorylation at Tyr-798 which induces PTPRA localization and recruitment of BCAR3, BCAR1 and CRK to focal adhesions. |
| Function | Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase Alpha Protein-Tyrosine Phosphatase Alpha R-Ptp-Alpha |
| Database Links | Reactome: R-HSA-375165 Reactome: R-HSA-5673001 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Cell Junction Focal Adhesion Localizes To Focal Adhesion Sites Following Integrin Engagement |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase Alpha antibody Anti-Protein-Tyrosine Phosphatase Alpha antibody Anti-R-Ptp-Alpha antibody Anti-PTPRA antibody Anti-PTPA antibody Anti-PTPRL2 antibody |
Information sourced from Uniprot.org