| Post Translational Modifications | GlcNAcylation at Ser-529 by OGT decreases enzyme activity, leading to redirect glucose flux through the oxidative pentose phosphate pathway. Glycosylation is stimulated by both hypoxia and glucose deprivation. |
| Function | Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway. |
| Protein Name | Atp-Dependent 6-Phosphofructokinase - Liver TypeAtp-PfkPfk-L6-Phosphofructokinase Type BPhosphofructo-1-Kinase Isozyme BPfk-BPhosphohexokinase |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-70171 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Atp-Dependent 6-Phosphofructokinase - Liver Type antibodyAnti-Atp-Pfk antibodyAnti-Pfk-L antibodyAnti-6-Phosphofructokinase Type B antibodyAnti-Phosphofructo-1-Kinase Isozyme B antibodyAnti-Pfk-B antibodyAnti-Phosphohexokinase antibodyAnti-PFKL antibody |
Information sourced from Uniprot.org
