Anti-PDE7A antibody (345-456) (STJ117273)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PDE7A (345-456) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDE7A |
| Gene ID | 5150 |
| Uniprot ID | PDE7A_HUMAN |
| Immunogen Region | 345-456 |
| Immunogen Sequence | ELSKQWSEKVTEEFFHQGDI EKKYHLGVSPLCDRHTESIA NIQIGFMTYLVEPLFTEWAR FSNTRLSQTMLGHVGLNKAS WKGLQREQSSSEDTDAAFEL NSQLLPQENRLS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 345-456 of human PDE7A (NP_002594.1). |
Additional Info
| Tissue Specificity | Isoform PDE7A1: Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. Isoform PDE7A2: Found abundantly in skeletal muscle and at low levels in heart. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. |
| Protein Name | High Affinity 3' -5'-Cyclic-Amp Phosphodiesterase 7aHcp1Tm22Camp-Specific Phosphodiesterase 7a |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | Isoform Pde7a1: CytoplasmCytosolPde7a1 (57 Kda) Is Located Mostly To Soluble Cellular FractionsIsoform Pde7a2: CytoplasmPde7a2 (50 Kda) Is Located To Particulate Cellular Fractions |
| Alternative Antibody Names | Anti-High Affinity 3' -5'-Cyclic-Amp Phosphodiesterase 7a antibodyAnti-Hcp1 antibodyAnti-Tm22 antibodyAnti-Camp-Specific Phosphodiesterase 7a antibodyAnti-PDE7A antibody |
Information sourced from Uniprot.org