| Short Description : | Rabbit polyclonal PDE7A (345-456) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PDE7A |
| Gene ID: | 5150 |
| Uniprot ID: | PDE7A_HUMAN |
| Immunogen Region: | 345-456 |
| Immunogen Sequence: | ELSKQWSEKVTEEFFHQGDI EKKYHLGVSPLCDRHTESIA NIQIGFMTYLVEPLFTEWAR FSNTRLSQTMLGHVGLNKAS WKGLQREQSSSEDTDAAFEL NSQLLPQENRLS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 345-456 of human PDE7A (NP_002594.1). |
| Tissue Specificity | Isoform PDE7A1: Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. Isoform PDE7A2: Found abundantly in skeletal muscle and at low levels in heart. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. |
| Protein Name | High Affinity 3' -5'-Cyclic-Amp Phosphodiesterase 7aHcp1Tm22Camp-Specific Phosphodiesterase 7a |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | Isoform Pde7a1: CytoplasmCytosolPde7a1 (57 Kda) Is Located Mostly To Soluble Cellular FractionsIsoform Pde7a2: CytoplasmPde7a2 (50 Kda) Is Located To Particulate Cellular Fractions |
| Alternative Antibody Names | Anti-High Affinity 3' -5'-Cyclic-Amp Phosphodiesterase 7a antibodyAnti-Hcp1 antibodyAnti-Tm22 antibodyAnti-Camp-Specific Phosphodiesterase 7a antibodyAnti-PDE7A antibody |
Information sourced from Uniprot.org
