Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-PARD6A (1-100) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | PARD6A |
Gene ID: | 50855 |
Uniprot ID: | PAR6A_HUMAN |
Immunogen Region: | 1-100 |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PARD6A (Q9NPB6). |
Immunogen Sequence: | MARPQRTPARSPDSIVEVKS KFDAEFRRFALPRASVSGFQ EFSRLLRAVHQIPGLDVLLG YTDAHGDLLPLTNDDSLHRA LASGPPPLRLLVQKRAEADS |
Tissue Specificity | Expressed in pancreas, skeletal muscle, brain and heart. Weakly expressed in kidney and placenta. |
Post Translational Modifications | Phosphorylated by the TGF-beta receptor. |
Function | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization. |
Protein Name | Partitioning Defective 6 Homolog Alpha Par-6 Par-6 Alpha Par-6a Par6c Tax Interaction Protein 40 Tip-40 |
Database Links | Reactome: R-HSA-2173791 Reactome: R-HSA-420029 Reactome: R-HSA-4608870 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013420 Reactome: R-HSA-9013424 |
Cellular Localisation | Cytoplasm Cell Membrane Cell Projection Ruffle Cell Junction Tight Junction Cytoskeleton Microtubule Organizing Center Centrosome Centriolar Satellite Colocalizes With Gtp-Bound Cdc42 Or Rac1 At Membrane Ruffles And With Pard3 And Prkci At Epithelial Tight Junctions Recruited To The Centrosome By A Microtubule And Dynein-Dynactin-Dependent Mechanism |
Alternative Antibody Names | Anti-Partitioning Defective 6 Homolog Alpha antibody Anti-Par-6 antibody Anti-Par-6 Alpha antibody Anti-Par-6a antibody Anti-Par6c antibody Anti-Tax Interaction Protein 40 antibody Anti-Tip-40 antibody Anti-PARD6A antibody Anti-PAR6A antibody |
Information sourced from Uniprot.org