Anti-PACSIN2 antibody (240-410) (STJ11104300)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2 (240-410) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PACSIN2 |
| Gene ID | 11252 |
| Uniprot ID | PACN2_HUMAN |
| Immunogen Region | 240-410 |
| Immunogen Sequence | RLRFFREVLLEVQKHLDLSN VAGYKAIYHDLEQSIRAADA VEDLRWFRANHGPGMAMNWP QFEEWSADLNRTLSRREKKK ATDGVTLTGINQTGDQSLPS KPSSTLNVPSNPAQSAQSQS SYNPFEDEDDTGSTVSEKDD TKAKNVSSYEKTQSYPTDWS DDESNNPFSST |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 240-410 of human PACSIN2 (NP_009160.2). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae. |
| Function | Regulates the morphogenesis and endocytosis of caveolae. Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells. (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer. Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes. Involved in lipid droplet formation, which is important for HCV virion assembly. |
| Protein Name | Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2Syndapin-2Syndapin-IiSdpii |
| Database Links | Reactome: R-HSA-8856828 |
| Cellular Localisation | CytoplasmCytoskeletonCytoplasmic Vesicle MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionRuffle MembraneEarly EndosomeRecycling Endosome MembraneCell MembraneMembraneCaveolaCell JunctionAdherens JunctionDetected At The Neck Of Flask-Shaped CaveolaeLocalization To Tubular Recycling Endosomes Probably Requires Interaction With Micall1 And Ehd1 |
| Alternative Antibody Names | Anti-Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2 antibodyAnti-Syndapin-2 antibodyAnti-Syndapin-Ii antibodyAnti-Sdpii antibodyAnti-PACSIN2 antibody |
Information sourced from Uniprot.org