Anti-OSBPL2 antibody (291-480) (STJ116433)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal OSBPL2 (291-480) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OSBPL2 |
| Gene ID | 9885 |
| Uniprot ID | OSBL2_HUMAN |
| Immunogen Region | 291-480 |
| Immunogen Sequence | NKKKLFMIYGKWTECLWGID PVSYESFKKQERRGDHLRKA KLDEDSGKADSDVADDVPVA QETVQVIPGSKLLWRINTRP PNSAQMYNFTSFTVSLNELE TGMEKTLPPTDCRLRPDIRG MENGNMDLASQEKERLEEKQ REARRERAKEEAEWQTRWFY PGNNPYTGTPDWLYAGDYFE RNFSDCPDIY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 291-480 of human OSBPL2 (NP_653081.1). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro). |
| Protein Name | Oxysterol-Binding Protein-Related Protein 2Orp-2Osbp-Related Protein 2 |
| Database Links | Reactome: R-HSA-192105 |
| Cellular Localisation | CytoplasmCytosolLipid DropletCell MembranePeripheral Membrane ProteinCytoplasmic SideDetected On The Surface Of Cytosolic Lipid DropletsRecruited To The Cell Membrane By Phosphatidylinositol-Phosphate Binding |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 2 antibodyAnti-Orp-2 antibodyAnti-Osbp-Related Protein 2 antibodyAnti-OSBPL2 antibodyAnti-KIAA0772 antibodyAnti-ORP2 antibody |
Information sourced from Uniprot.org