| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | OSBPL2 |
| Gene ID: | 9885 |
| Uniprot ID: | OSBL2_HUMAN |
| Immunogen Region: | 291-480 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 291-480 of human OSBPL2 (NP_653081.1). |
| Immunogen Sequence: | NKKKLFMIYGKWTECLWGID PVSYESFKKQERRGDHLRKA KLDEDSGKADSDVADDVPVA QETVQVIPGSKLLWRINTRP PNSAQMYNFTSFTVSLNELE TGMEKTLPPTDCRLRPDIRG MENGNMDLASQEKERLEEKQ REARRERAKEEAEWQTRWFY PGNNPYTGTPDWLYAGDYFE RNFSDCPDIY |
| Tissue Specificity | Widely expressed. |
| Function | Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5-bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro). |
| Protein Name | Oxysterol-Binding Protein-Related Protein 2 Orp-2 Osbp-Related Protein 2 |
| Database Links | Reactome: R-HSA-192105 |
| Cellular Localisation | Cytoplasm Cytosol Lipid Droplet Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Detected On The Surface Of Cytosolic Lipid Droplets Recruited To The Cell Membrane By Phosphatidylinositol-Phosphate Binding |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 2 antibody Anti-Orp-2 antibody Anti-Osbp-Related Protein 2 antibody Anti-OSBPL2 antibody Anti-KIAA0772 antibody Anti-ORP2 antibody |
Information sourced from Uniprot.org