Anti-NR2E1 antibody (1-100) [S2MR] (STJ11102372)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal NR2E1 (1-100) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NR2E1 |
| Gene ID | 7101 |
| Uniprot ID | NR2E1_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MSKPAGSTSRILDIPCKVCG DRSSGKHYGVYACDGCSGFF KRSIRRNRTYVCKSGNQGGC PVDKTHRNQCRACRLKKCLE VNMNKDAVQHERGPRTSTIR |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NR2E1 (Q9Y466). |
Additional Info
| Tissue Specificity | Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acid receptor (RAR) regulation in retinal cells. |
| Protein Name | Nuclear Receptor Subfamily 2 Group E Member 1Nuclear Receptor TlxProtein Tailless HomologTllHtll |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-8943724 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 2 Group E Member 1 antibodyAnti-Nuclear Receptor Tlx antibodyAnti-Protein Tailless Homolog antibodyAnti-Tll antibodyAnti-Htll antibodyAnti-NR2E1 antibodyAnti-TLX antibody |
Information sourced from Uniprot.org