| Tissue Specificity | Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. |
| Function | Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acid receptor (RAR) regulation in retinal cells. |
| Protein Name | Nuclear Receptor Subfamily 2 Group E Member 1Nuclear Receptor TlxProtein Tailless HomologTllHtll |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-8943724 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 2 Group E Member 1 antibodyAnti-Nuclear Receptor Tlx antibodyAnti-Protein Tailless Homolog antibodyAnti-Tll antibodyAnti-Htll antibodyAnti-NR2E1 antibodyAnti-TLX antibody |
Information sourced from Uniprot.org
