• Western blot analysis of extracts of various cell lines, using NR2E1/TLX rabbit monoclonal antibody (STJ11102372) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.
  • Western blot analysis of various lysates using NR2E1/TLX Rabbit monoclonal antibody (STJ11102372) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.

Anti-NR2E1 antibody (1-100) [S2MR] (STJ11102372)

SKU:
STJ11102372

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-NR2E1 (1-100) is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Clone ID: S2MR
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NR2E1
Gene ID: 7101
Uniprot ID: NR2E1_HUMAN
Immunogen Region: 1-100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NR2E1 (Q9Y466).
Immunogen Sequence: MSKPAGSTSRILDIPCKVCG DRSSGKHYGVYACDGCSGFF KRSIRRNRTYVCKSGNQGGC PVDKTHRNQCRACRLKKCLE VNMNKDAVQHERGPRTSTIR
Tissue Specificity Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.
Function Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity. May be involved in retinoic acid receptor (RAR) regulation in retinal cells.
Protein Name Nuclear Receptor Subfamily 2 Group E Member 1
Nuclear Receptor Tlx
Protein Tailless Homolog
Tll
Htll
Database Links Reactome: R-HSA-383280
Reactome: R-HSA-8943724
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Nuclear Receptor Subfamily 2 Group E Member 1 antibody
Anti-Nuclear Receptor Tlx antibody
Anti-Protein Tailless Homolog antibody
Anti-Tll antibody
Anti-Htll antibody
Anti-NR2E1 antibody
Anti-TLX antibody

Information sourced from Uniprot.org

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