Anti-NKX3.1 antibody (1-234) [S0MR] (STJ11103100)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal NKX3.1 (1-234) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S0MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NKX3-1 |
| Gene ID | 4824 |
| Uniprot ID | NKX31_HUMAN |
| Immunogen Region | 1-234 |
| Immunogen Sequence | MLRVPEPRPGEAKAEGAAPP TPSKPLTSFLIQDILRDGAQ RQGGRTSSQRQRDPEPEPEP EPEGGRSRAGAQNDQLSTGP RAAPEEAETLAETEPERHLG SYLLDSENTSGALPRLPQTP KQPQKRSRAAFSHTQVIELE RKFSHQKYLSAPERAHLAKN LKLTETQVKIWFQNRRYKTK RKQLSSELGDLEKHSSLPAL KEEAFSRASLVSVYNSYPYY PYLYCVGSWSPAFW |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human NKX3.1 (Q99801). |
Additional Info
| Tissue Specificity | Highly expressed in the prostate and, at a lower level, in the testis. |
| Post Translational Modifications | Ubiquitinated by TOPORS.monoubiquitinated at several residues and also polyubiquitinated on single residues. |
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGTAG-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. |
| Protein Name | Homeobox Protein Nkx-3.1Homeobox Protein Nk-3 Homolog A |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-3.1 antibodyAnti-Homeobox Protein Nk-3 Homolog A antibodyAnti-NKX3-1 antibodyAnti-NKX3.1 antibodyAnti-NKX3A antibody |
Information sourced from Uniprot.org