| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S0MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NKX3-1 |
| Gene ID: | 4824 |
| Uniprot ID: | NKX31_HUMAN |
| Immunogen Region: | 1-234 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-234 of human NKX3.1 (Q99801). |
| Immunogen Sequence: | MLRVPEPRPGEAKAEGAAPP TPSKPLTSFLIQDILRDGAQ RQGGRTSSQRQRDPEPEPEP EPEGGRSRAGAQNDQLSTGP RAAPEEAETLAETEPERHLG SYLLDSENTSGALPRLPQTP KQPQKRSRAAFSHTQVIELE RKFSHQKYLSAPERAHLAKN LKLTETQVKIWFQNRRYKTK RKQLSSELGDLEKHSSLPAL KEEAFSRASLVSVYNSYPYY PYLYCVGSWSPAFW |
| Tissue Specificity | Highly expressed in the prostate and, at a lower level, in the testis. |
| Post Translational Modifications | Ubiquitinated by TOPORS.monoubiquitinated at several residues and also polyubiquitinated on single residues. |
| Function | Transcription factor, which binds preferentially the consensus sequence 5'-TAAGTAG-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. |
| Protein Name | Homeobox Protein Nkx-3.1Homeobox Protein Nk-3 Homolog A |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Homeobox Protein Nkx-3.1 antibodyAnti-Homeobox Protein Nk-3 Homolog A antibodyAnti-NKX3-1 antibodyAnti-NKX3.1 antibodyAnti-NKX3A antibody |
Information sourced from Uniprot.org