| Function | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Also permeable to Mg(2+), Na(+) and K(+). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3. |
| Protein Name | Mucolipin-3Transient Receptor Potential Channel Mucolipin 3Trpml3 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneLate Endosome MembraneLysosome MembraneCytoplasmic VesicleAutophagosome MembraneRecycles Between The Plasma Membrane And Intracellular Compartments By A Dynamin-Dependent Endocytic PathwayUnder Normal ConditionsOnly A Very Minor Proportion Is Present At The Cell MembraneIn The Cochlea Located At The Base Of Stereocilia Near The Position Of The Ankle Links |
| Alternative Antibody Names | Anti-Mucolipin-3 antibodyAnti-Transient Receptor Potential Channel Mucolipin 3 antibodyAnti-Trpml3 antibodyAnti-MCOLN3 antibody |
Information sourced from Uniprot.org
