| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Mucolipin 3 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
MCOLN3 |
| Gene ID: |
55283 |
| Uniprot ID: |
MCLN3_HUMAN |
| Specificity: |
Specific for Mucolipin 3. |
| Immunogen: |
A synthetic peptide from human Mucolipin 3 conjugated to blue carrier protein was used as the antigen. |
| Function | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Also permeable to Mg(2+), Na(+) and K(+). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3. |
| Protein Name | Mucolipin-3Transient Receptor Potential Channel Mucolipin 3Trpml3 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneLate Endosome MembraneLysosome MembraneCytoplasmic VesicleAutophagosome MembraneRecycles Between The Plasma Membrane And Intracellular Compartments By A Dynamin-Dependent Endocytic PathwayUnder Normal ConditionsOnly A Very Minor Proportion Is Present At The Cell MembraneIn The Cochlea Located At The Base Of Stereocilia Near The Position Of The Ankle Links |
| Alternative Antibody Names | Anti-Mucolipin-3 antibodyAnti-Transient Receptor Potential Channel Mucolipin 3 antibodyAnti-Trpml3 antibodyAnti-MCOLN3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
