Anti-Mucolipin 3 antibody (STJ13100250)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from human Mucolipin 3 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-Mucolipin 3 for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | MCOLN3 |
| Gene ID | 55283 |
| Uniprot ID | MCLN3_HUMAN |
| Immunogen | A synthetic peptide from human Mucolipin 3 conjugated to blue carrier protein was used as the antigen. |
| Specificity | Specific for Mucolipin 3. |
Additional Info
| Function | Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity. Mediates release of Ca(2+) from endosomes to the cytoplasm, contributes to endosomal acidification and is involved in the regulation of membrane trafficking and fusion in the endosomal pathway. Also permeable to Mg(2+), Na(+) and K(+). Does not seem to act as mechanosensory transduction channel in inner ear sensory hair cells. Proposed to play a critical role at the cochlear stereocilia ankle-link region during hair-bundle growth. Involved in the regulation of autophagy. Through association with GABARAPL2 may be involved in autophagosome formation possibly providing Ca(2+) for the fusion process. Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Possible heteromeric ion channel assemblies with TRPV5 show pharmacological similarity with TRPML3. |
| Protein Name | Mucolipin-3Transient Receptor Potential Channel Mucolipin 3Trpml3 |
| Database Links | Reactome: R-HSA-3295583 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneLate Endosome MembraneLysosome MembraneCytoplasmic VesicleAutophagosome MembraneRecycles Between The Plasma Membrane And Intracellular Compartments By A Dynamin-Dependent Endocytic PathwayUnder Normal ConditionsOnly A Very Minor Proportion Is Present At The Cell MembraneIn The Cochlea Located At The Base Of Stereocilia Near The Position Of The Ankle Links |
| Alternative Antibody Names | Anti-Mucolipin-3 antibodyAnti-Transient Receptor Potential Channel Mucolipin 3 antibodyAnti-Trpml3 antibodyAnti-MCOLN3 antibody |
Information sourced from Uniprot.org