| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MTPAP |
| Gene ID: | 55149 |
| Uniprot ID: | PAPD1_HUMAN |
| Immunogen Region: | 383-582 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 383-582 of human MTPAP (NP_060579.3). |
| Immunogen Sequence: | MVIFFLQRRSPPILPTLDSL KTLADAEDKCVIEGNNCTFV RDLSRIKPSQNTETLELLLK EFFEYFGNFAFDKNSINIRQ GREQNKPDSSPLYIQNPFET SLNISKNVSQSQLQKFVDLA RESAWILQQEDTDRPSISSN RPWGLVSLLLPSAPNRKSFT KKKSNKFAIETVKNLLESLK GNRTENFTKTSGKRTISTQT |
| Tissue Specificity | Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle. |
| Function | Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. |
| Protein Name | Poly(A Rna Polymerase - Mitochondrial Pap Pap-Associated Domain-Containing Protein 1 Polynucleotide Adenylyltransferase Terminal Uridylyltransferase 1 Tutase 1 Mtpap |
| Cellular Localisation | Cytoplasm Mitochondrion |
| Alternative Antibody Names | Anti-Poly(A Rna Polymerase - Mitochondrial antibody Anti-Pap antibody Anti-Pap-Associated Domain-Containing Protein 1 antibody Anti-Polynucleotide Adenylyltransferase antibody Anti-Terminal Uridylyltransferase 1 antibody Anti-Tutase 1 antibody Anti-Mtpap antibody Anti-MTPAP antibody Anti-PAPD1 antibody |
Information sourced from Uniprot.org