Anti-MTPAP antibody (383-582) (STJ119756)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MTPAP (383-582) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTPAP |
| Gene ID | 55149 |
| Uniprot ID | PAPD1_HUMAN |
| Immunogen Region | 383-582 |
| Immunogen Sequence | MVIFFLQRRSPPILPTLDSL KTLADAEDKCVIEGNNCTFV RDLSRIKPSQNTETLELLLK EFFEYFGNFAFDKNSINIRQ GREQNKPDSSPLYIQNPFET SLNISKNVSQSQLQKFVDLA RESAWILQQEDTDRPSISSN RPWGLVSLLLPSAPNRKSFT KKKSNKFAIETVKNLLESLK GNRTENFTKTSGKRTISTQT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 383-582 of human MTPAP (NP_060579.3). |
Additional Info
| Tissue Specificity | Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle. |
| Function | Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. |
| Protein Name | Poly(A Rna Polymerase - MitochondrialPapPap-Associated Domain-Containing Protein 1Polynucleotide AdenylyltransferaseTerminal Uridylyltransferase 1Tutase 1Mtpap |
| Database Links | |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Poly(A Rna Polymerase - Mitochondrial antibodyAnti-Pap antibodyAnti-Pap-Associated Domain-Containing Protein 1 antibodyAnti-Polynucleotide Adenylyltransferase antibodyAnti-Terminal Uridylyltransferase 1 antibodyAnti-Tutase 1 antibodyAnti-Mtpap antibodyAnti-MTPAP antibodyAnti-PAPD1 antibody |
Information sourced from Uniprot.org