| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MTPAP (383-582) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MTPAP |
| Gene ID: |
55149 |
| Uniprot ID: |
PAPD1_HUMAN |
| Immunogen Region: |
383-582 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 383-582 of human MTPAP (NP_060579.3). |
| Immunogen Sequence: |
MVIFFLQRRSPPILPTLDSL KTLADAEDKCVIEGNNCTFV RDLSRIKPSQNTETLELLLK EFFEYFGNFAFDKNSINIRQ GREQNKPDSSPLYIQNPFET SLNISKNVSQSQLQKFVDLA RESAWILQQEDTDRPSISSN RPWGLVSLLLPSAPNRKSFT KKKSNKFAIETVKNLLESLK GNRTENFTKTSGKRTISTQT |
| Tissue Specificity | Ubiquitous, with stronger expression in tissues with high energy requirements: heart, brain, and skeletal muscle. |
| Function | Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA. |
| Protein Name | Poly(A Rna Polymerase - MitochondrialPapPap-Associated Domain-Containing Protein 1Polynucleotide AdenylyltransferaseTerminal Uridylyltransferase 1Tutase 1Mtpap |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Poly(A Rna Polymerase - Mitochondrial antibodyAnti-Pap antibodyAnti-Pap-Associated Domain-Containing Protein 1 antibodyAnti-Polynucleotide Adenylyltransferase antibodyAnti-Terminal Uridylyltransferase 1 antibodyAnti-Tutase 1 antibodyAnti-Mtpap antibodyAnti-MTPAP antibodyAnti-PAPD1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
