| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MTMR3 |
| Gene ID: | 8897 |
| Uniprot ID: | MTMR3_HUMAN |
| Immunogen Region: | 640-810 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 640-810 of human MTMR3 (NP_066576.1). |
| Immunogen Sequence: | KWQEHRRSLELSSLAGPGED PLSADSLGKPTRVPGGAELS VAAGVAEGQMENILQEATKE ESGVEEPAHRAGIEIQEGKE DPLLEKESRRKTPEASAIGL HQDPELGDAALRSHLDMSWP LFSQGISEQQSGLSVLLSSL QVPPRGEDSLEVPVEQFRIE EIAEGREEAVL |
| Post Translational Modifications | Phosphorylated by CDK1 during mitosis. |
| Function | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic. Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis. |
| Protein Name | Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr3 Fyve Domain-Containing Dual Specificity Protein Phosphatase 1 Fyve-Dsp1 Myotubularin-Related Protein 3 Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Phosphatidylinositol-3-Phosphate Phosphatase Zinc Finger Fyve Domain-Containing Protein 10 |
| Database Links | Reactome: R-HSA-1632852 Reactome: R-HSA-1660499 |
| Cellular Localisation | Cytoplasm Cytosol Membrane Peripheral Membrane Protein |
| Alternative Antibody Names | Anti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr3 antibody Anti-Fyve Domain-Containing Dual Specificity Protein Phosphatase 1 antibody Anti-Fyve-Dsp1 antibody Anti-Myotubularin-Related Protein 3 antibody Anti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase antibody Anti-Phosphatidylinositol-3-Phosphate Phosphatase antibody Anti-Zinc Finger Fyve Domain-Containing Protein 10 antibody Anti-MTMR3 antibody Anti-KIAA0371 antibody Anti-ZFYVE10 antibody |
Information sourced from Uniprot.org