Anti-MTMR3 antibody (640-810) (STJ112702)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MTMR3 (640-810) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTMR3 |
| Gene ID | 8897 |
| Uniprot ID | MTMR3_HUMAN |
| Immunogen Region | 640-810 |
| Immunogen Sequence | KWQEHRRSLELSSLAGPGED PLSADSLGKPTRVPGGAELS VAAGVAEGQMENILQEATKE ESGVEEPAHRAGIEIQEGKE DPLLEKESRRKTPEASAIGL HQDPELGDAALRSHLDMSWP LFSQGISEQQSGLSVLLSSL QVPPRGEDSLEVPVEQFRIE EIAEGREEAVL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 640-810 of human MTMR3 (NP_066576.1). |
Additional Info
| Post Translational Modifications | Phosphorylated by CDK1 during mitosis. |
| Function | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic. Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis. |
| Protein Name | Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr3Fyve Domain-Containing Dual Specificity Protein Phosphatase 1Fyve-Dsp1Myotubularin-Related Protein 3Phosphatidylinositol-3 -5-Bisphosphate 3-PhosphatasePhosphatidylinositol-3-Phosphate PhosphataseZinc Finger Fyve Domain-Containing Protein 10 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-1660499 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr3 antibodyAnti-Fyve Domain-Containing Dual Specificity Protein Phosphatase 1 antibodyAnti-Fyve-Dsp1 antibodyAnti-Myotubularin-Related Protein 3 antibodyAnti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase antibodyAnti-Phosphatidylinositol-3-Phosphate Phosphatase antibodyAnti-Zinc Finger Fyve Domain-Containing Protein 10 antibodyAnti-MTMR3 antibodyAnti-KIAA0371 antibodyAnti-ZFYVE10 antibody |
Information sourced from Uniprot.org